A statistics professor at Southern University in Baton Rouge, Louisiana (Dr. Min Su Kim) looked at the Powerball drawings from the last ten years and determined there are numbers drawn more frequently than others.
Maybe this will help you try to win the jackpot.
The five most frequently drawn Powerball numbers (the red ball) are (in order):
20, 37, 2, 31, 35
The five most frequently drawn white ball numbers are (in order):
42, 16, 35, 26, 19
Update 11/29: The Powerball drawing last night didn't contain any of the most frequently drawn numbers (for the $570+ million dollar drawing). Statistics don't seem to have any bearing on matching up with winning.
The winning numbers for the 11/28/12 Powerball drawing were: 5, 16, 22, 23, 29 and the Powerball was 6.